A List of Scientific Studies and Research on Low Carb High Fat Diet – KetoVale

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A List of Scientific Studies and Research on Low Carb High Fat Diet

Amongst those who wish to be and stay healthy, there is a constant struggle to find a diet that fits perfectly with our needs and goals. It’s not uncommon for new fad diets to come and go every single year.

One dangerous trend that seems to apply to most of these “fashion diets” is the lack of studies proving their worth. However, the keto diet has actually been scientifically proven to have many benefits for health and weight loss. Keto has gained a huge amount of traction and publicity in the recent years.

With the current scientific data and research available, it has become apparent that the Ketogenic Diet not only offers a wide array of benefits, but it’s also a safe and reliable diet which can be followed for a long time.

We have also have a list of health benefits of keto diet in this ketogenic diet for beginners guide as well as the growing number of keto success stories we have received.

In order to dispel any possible doubts, we have decided to put together a short list of studies that prove the true value and scientific facts of the Ketogenic Diet. If you love science, dig into these studies and learn more about them.

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Studies and Research on Low Carb High Fat Diet

Group 1: Studies that focus specifically on Keto Diet

  1. A Critique of Low-Carbohydrate Ketogenic Weight Reduction Regimens (Council on Foods and Nutrition of the American Medical Association, 1973) – Source
  2. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. (Bueno et al., 2013) – Source
  3. Ketogenic Diet for Obesity: Friend or Foe? (Paoli, 2014) – Source
  4. Ketosis, ketogenic diet and food intake control: a complex relationship (Paoli et al., 2015) – Source
  5. Fat-Free Mass Changes During Ketogenic Diets and the Potential Role of Resistance Training (Tinsley and Willoughby, 2016) – Source
  6. International society of sports nutrition position stand: diets and body composition (Aragon et al., 2017) – Source
  7. Composition of weight lost during short-term weight reduction. Metabolic responses of obese subjects to starvation and low-calorie ketogenic and nonketogenic diets (Yang and Itallie, 1976) – Source
  8. Protein sparing during treatment of obesity: ketogenic versus nonketogenic very low calorie diet (Vazquez and Adibi, 1992) – Source
  9. The effects of a high-protein, low-fat, ketogenic diet on adolescents with morbid obesity: body composition, blood chemistries, and sleep abnormalities (Willi et al., 1998) – Source
  10. Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women (Volek et al., 2004) – Source
  11. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum (Johnstone et al., 2008) – Source
  12. Resistance training in overweight women on a ketogenic diet conserved lean body mass while reducing body fat (Jabekk et al., 2010) – Source
  13. Ketogenic diet does not affect strength performance in elite artistic gymnasts (Paoli et al., 2012) – Source
  14. The effect of weight loss by ketogenic diet on the body composition, performance-related physical fitness factors and cytokines of Taekwondo athletes (Rhyu and Cho, 2014) – Source
  15. The effects of ketogenic dieting on skeletal muscle and fat mass (Rauch et al., 2014) – Source
  16. Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus (Goday et al., 2016) – Source
  17. Very-low-calorie ketogenic diet with aminoacid supplement versus very low restricted-calorie diet for preserving muscle mass during weight loss: a pilot double-blind study (Merra et al., 2016) – Source
  18. A Low-Carbohydrate Ketogenic Diet Combined with 6-Weeks of Crossfit Training Improves Body Composition and Performance (Gregory et al., 2017) – Sources
  19. The Effects of Ketogenic Dieting on Body Composition, Strength, Power, and Hormonal Profiles in Resistance Training Males (Wilson et al., 2017) – Sources
  20. Efficacy and safety of very-low-calorie ketogenic diet: a double blind randomized crossover study (Colica et al., 2017) – Source
  21. Capacity for Moderate Exercise in Obese Subjects after Adaptation to a Hypocaloric, Ketogenic Diet (Phinney et al., 1980) – Source
  22. Ketogenic diets and physical performance (Phinney, 2004) – Source
  23. Acute nutritional ketosis: implications for exercise performance and metabolism (Cox and Clarke, 2014) – Source
  24. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes (Cox et al., 2016) – Source
  25. The Effects of a Ketogenic Diet on Exercise Metabolism and Physical Performance in Off-Road Cyclists (Zajac et al., 2014) – Source
  26. Metabolic characteristics of keto-adapted ultra-endurance runners (Volek et al., 2016) – Source
  27. Ketogenic diet benefits body composition and well-being but not performance in a pilot case study of New Zealand endurance athletes (Zinn et al., 2017) – Source
  28. Clinical Aspects of the Ketogenic Diet (Hartman and Vining, 2007) – Source
  29. A low-carbohydrate, ketogenic diet to treat type 2 diabetes (Yancy et al., 2005) – Source
  30. Beneficial effects of ketogenic diet in obese diabetic subjects (Dashti et al., 2007) – Source
  31. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus (Westman et al., 2008) – Source
  32. Effect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes (Hussain et al., 2012) – Source
  33. An Online Intervention Comparing a Very Low-Carbohydrate Ketogenic Diet and Lifestyle Recommendations Versus a Plate Method Diet in Overweight Individuals With Type 2 Diabetes: A Randomized Controlled Trial (Saslow et al., 2017) – Source
  34. Effects of Ketogenic Diets on Cardiovascular Risk Factors: Evidence from Animal and Human Studies (Kosinski and Jornayvaz, 2017) – Source
  35. The AMP-Activated Protein Kinase Is Involved in the Regulation of Ketone Body Production by Astrocytes (Blázquez et al., 1999) – Source
  36. The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer (Zhou et al., 2007) – Source
  37. Role of ketogenic metabolic therapy in malignant glioma: A systematic review (Winter et al., 2017) – Source
  38. A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review (Oliveira et al., 2017) – Source
  39. Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation (Klement, 2017) – Source
  40. Systematic review: isocaloric ketogenic dietary regimes for cancer patients (Erickson et al., 2017) – Source
  41. Assessing the Role of the Ketogenic Diet as a Metabolic Therapy in Cancer: Is it Evidence Based? (Macias and Sharpe, 2017) – Source
  42. Pleiotropic effects of nutritional ketosis: Conceptual framework for keto-adaptation as a breast cancer therapy (Hyde et al., 2017) – Source
  43. A Multicenter Study of the Efficacy of the Ketogenic Diet (Vining et al., 1998) – Source
  44. Ketogenic diet for the treatment of refractory epilepsy in children: A systematic review of efficacy (Lefevre and Aronson, 2000) – Source
  45. Fasting versus Gradual Initiation of the Ketogenic Diet: A Prospective, Randomized Clinical Trial of Efficacy (Bergqvist et al., 2005) – Source
  46. Efficacy of the Ketogenic Diet as a Treatment Option for Epilepsy: Meta-analysis (Henderson et al., 2006) – Source
  47. The ketogenic diet: From molecular mechanisms to clinical effects (Freeman et al., 2006) – Source
  48. The Neuropharmacology of the Ketogenic Diet (Hartman et al., 2007) – Source
  49. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial (Neal et al., 2008) – Source
  50. Ketogenic diet for treatment of epilepsy (Rogovik and Goldman, 2010) – Source
  51. The ketogenic diet: metabolic influences on brain excitability and epilepsy (Lutas and Yellen, 2013) – Source
  52. Is Ketogenic Diet Truly Effective in Mitochondrial Epilepsy? (Finsterer and Kothari et al., 2014) – Source
  53. Dietary and Medication Adjustments to Improve Seizure Control in Patients Treated With the Ketogenic Diet (Selter et al., 2014) – Source
  54. Ketogenic diet in adolescents and adults with epilepsy (Nei et al., 2014) – Source
  55. Ketogenic diet and other dietary treatments for epilepsy (Martin et al., 2016) – Source
  56. A randomized controlled trial of the ketogenic diet in refractory childhood epilepsy (Lambrechts et al., 2016) – Source
  57. Impact of a Modified Ketogenic Diet on Seizure Activity, Biochemical Markers, Anthropometrics and Gastrointestinal Symptoms in Adults with Epilepsy (Schuchmann et al., 2017) – Source
  58. How does the ketogenic diet induce anti-seizure effects? (Rho, 2017) – Source
  59. Efficacy of ketogenic diet in resistant myoclono-astatic epilepsy: A french multicenter retrospective study (de Saint-Martin et al., 2017) – Source
  60. The role for ketogenic diets in epilepsy and status epilepticus in adults (Williams et al., 2017) – Source
  61. Long-term effects of a ketogenic diet in obese patients (Dashti et al., 2004) – Source
  62. Neuroprotective and disease-modifying effects of the ketogenic diet (Gasior et al., 2006) – Source
  63. Timeline of changes in appetite during weight loss with a ketogenic diet (Nymo et al., 2017) – Source
  64. Ketogenic diet in migraine: rationale, findings and perspectives (Barbanti et al., 2017) – Source
  65. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies (Maalouf et al., 2009) – Source
  66. A Ketogenic Diet Favorably Affects Serum Biomarkers for Cardiovascular Disease in Normal-Weight Men (Sharman et al., 2002) – Source
  67. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice (Roberts et al., 2017) – Source
  68. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice (Newman et al., 2017) – Source

Group 2: Study focuses on low carb high fat diet or just low carb diet

  1. A Critique of Low-Carbohydrate Ketogenic Weight Reduction Regimens (Council on Foods and Nutrition of the American Medical Association, 1973) – Source
  2. Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss? (Astrup et al., 2004) – Source
  3. Very-low-carbohydrate diets and preservation of muscle mass (Manninen, 2006) – Source
  4. Low-Carbohydrate Diets Promote a More Favorable Body Composition Than Low-Fat Diets (Volek et al., 2010) – Source
  5. Effects of Low-Carbohydrate Diets Versus Low-Fat Diets on Metabolic Risk Factors: A Meta-Analysis of Randomized Controlled Clinical Trials (Hu et al., 2012) – Source
  6. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. (Bueno et al., 2013) – Source
  7. Evidence that supports the prescription of low-carbohydrate high-fat diets: a narrative review (Noakes and Windt, 2016) – Source
  8. International society of sports nutrition position stand: diets and body composition (Aragon et al., 2017) – Source
  9. Body composition and hormonal responses to a carbohydrate-restricted diet (Volek et al., 2002) – Source
  10. Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets (Johnston et al., 2006) – Source
  11. Effects of Low-Carbohydrate and Low-Fat Diets: A Randomized Trial (Bazzano et al., 2014) – Source
  12. Adherence to low-carbohydrate and low-fat diets in relation to weight loss and cardiovascular risk factors (Hu et al., 2016) – Source
  13. The effect of an 8-week low carbohydrate high fat (LCHF) diet in sub-elite Olympic weightlifters and powerlifters on strength, body composition, mental state and adherence: a pilot case-study (Chatterton et al., 2017) – Source
  14. A Low-Carbohydrate Ketogenic Diet Combined with 6-Weeks of Crossfit Training Improves Body Composition and Performance (Gregory et al., 2017) – Source
  15. Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans (Helge et al., 2001) – Source
  16. Low-carbohydrate nutrition and metabolism (Westman et al., 2007) – Source
  17. Carbohydrates and exercise performance in non-fasted athletes: A systematic review of studies mimicking real-life (Colombani et al., 2013) – Source
  18. The use of carbohydrates during exercise as an ergogenic aid (Cermak and van Loon, 2013) – Source
  19. Re-Examining High-Fat Diets for Sports Performance: Did We Call the ‘Nail in the Coffin’ Too Soon? (Burke, 2015) – Source
  20. Gluconeogenesis during endurance exercise in cyclists habituated to a long-term low carbohydrate high-fat diet (Webster et al., 2016) – Source
  21. Differential in Maximal Aerobic Capacity by Sex in Collegiate Endurance Athletes Consuming a Marginally Low Carbohydrate Diet (Baranauskas et al., 2017) – Source
  22. Low-Carbohydrate-High-Fat Diet: Can it Help Exercise Performance? (Chang et al., 2017) – Source
  23. Improvement of gastroesophageal reflux disease after initiation of a low-carbohydrate diet: five brief case reports (Yancy et al., 2001) – Source
  24. A Very Low-Carbohydrate Diet Improves Gastroesophageal Reflux and Its Symptoms (Austin et al., 2006) – Source
  25. Systematic review: the effects of conservative and surgical treatment for obesity on gastro-oesophageal reflux disease (De Groot et al., 2009) – Source
  26. Dietary carbohydrate intake, insulin resistance and gastro-oesophageal reflux disease: a pilot study in European- and African-American obese women (Pointer et al., 2016) – Source
  27. A low-carbohydrate as compared with a low-fat diet in severe obesity (Samaha et al., 2003) – Source
  28. Effect of a Low-Carbohydrate Diet on Appetite, Blood Glucose Levels, and Insulin Resistance in Obese Patients with Type 2 Diabetes (Boden et al., 2005) – Source
  29. A low-carbohydrate, ketogenic diet to treat type 2 diabetes (Yancy et al., 2005) – Source
  30. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus (Westman et al., 2008) – Source
  31. A critical review of low-carbohydrate diets in people with Type 2 diabetes (van Wyk et al., 2013) – Source
  32. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base (Feinman et al., 2015) – Source
  33. Is there a role for carbohydrate restriction in the treatment and prevention of cancer? (Klement and Kämmerer, 2011) – Source
  34. Low-carbohydrate nutrition and metabolism (Westman et al., 2007) – Source
  35. Vascular effects of a low-carbohydrate high-protein diet (Foo et al., 2009) – Source
  36. Effect of 6-month adherence to a very low carbohydrate diet program (Westman et al., 2002) – Source
  37. Adherence and success in long-term weight loss diets: the dietary intervention randomized controlled trial (DIRECT) (Greenberg et al., 2009) – Source

Group 3: Studies that show carbs are bad  

  1. Body composition and hormonal responses to a carbohydrate-restricted diet (Volek et al., 2002) – Source
  2. Carbohydrate intake and resistance-based exercise: are current recommendations reflective of actual need (Escobar et al., 2016) – Source

Group 4: Studies that show fats are good

  1. Evidence that supports the prescription of low-carbohydrate high-fat diets: a narrative review (Noakes and Windt, 2016) – Source
  2. Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects (Ruth et al., 2013) – Source
  3. The effect of an 8-week low carbohydrate high fat (LCHF) diet in sub-elite Olympic weightlifters and powerlifters on strength, body composition, mental state and adherence: a pilot case-study (Chatterton et al., 2017) – Source
  4. Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein-triacylglycerol in humans (Helge et al., 2001) – Source
  5. Re-Examining High-Fat Diets for Sports Performance: Did We Call the ‘Nail in the Coffin’ Too Soon? (Burke, 2015) – Source
  6. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study (Dehghan et al., 2017) – Source

Final thoughts

Although these are just some studies on the low carb high fat and ketogenic diets, it is also important to mention there are thousands of published studies on this topic and many, many more are still in progress and unpublished. With time and as technology advances, we can find more proofs that the Ketogenic Diet’s benefits will be further cemented.

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