Key Takeaways
- Researchers developed light-activated molecules that physically disrupt cancer cell membranes.
- This method uses near-infrared light, avoiding heat or chemical reactions.
- Over 99% of human melanoma cells were destroyed in lab tests.
- In mice, 50% treated with this method became tumor-free.
- The technique may prevent cancer cells from developing resistance.
A new study introduces a method to kill cancer cells using light-activated molecules that physically disrupt cell membranes. This approach, tested on human melanoma cells and in mice, avoids heat or chemical reactions, potentially offering a new avenue for cancer treatment.
How the Technique Works
Researchers utilized aminocyanines, molecules that attach to cancer cell membranes. When exposed to near-infrared light, these molecules undergo rapid vibrations, mechanically disrupting the cell membranes and causing cell death. This process, termed vibronic-driven action (VDA), differs from traditional photodynamic or photothermal therapies.
Laboratory and Animal Testing
In Vitro Results
In laboratory experiments, exposing human melanoma cells to aminocyanines and near-infrared light resulted in over 99% cell death. This was achieved without increasing the temperature of the surrounding environment.
In Vivo Results
In mouse models with melanoma tumors, treatment with this method led to a 60% survival rate at 120 days, with 50% of the mice becoming tumor-free.
Advantages Over Traditional Therapies
This technique operates independently of reactive oxygen species and does not rely on heat, making it distinct from existing therapies. Its mechanical approach may also reduce the likelihood of cancer cells developing resistance.
Future Implications
While these findings are promising, further research is needed to assess the safety and effectiveness of this method in humans. The study suggests a potential new direction for cancer treatment, focusing on mechanical disruption rather than chemical intervention.
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